Research Gate: Pharmaceutical Science

By K.REETHIKA, B. APU ASHARUDEEN

Background & Objective: Management of Type 2 Diabetes Mellitus (T2DM) requires strict, lifelong adherence to pharmacotherapy. Dysphagia affects roughly 35% of the population, presenting a barrier to oral solid dosage forms. Teneligliptin Hydrobromide, a novel peptidomimetic Dipeptidyl Peptidase-4 (DPP-4) inhibitor (BCS Class II), suffers from rate-limiting dissolution in gastrointestinal fluids. This study aimed to formulate, optimize, and comparatively evaluate Teneligliptin Hydrobromide Oral Dispersible Tablets (ODTs) using Plantago ovata (Isabgol) mucilage as a natural superdisintegrant against Crospovidone, a synthetic benchmark.

By B.Apu Asharudeen, S. PrasannaKumar, A.P.Priyanka , A. Renuga Devi, R. Rajamani

This research focused on the development and assessment of Citicoline orally disintegrating. tablets (ODTs) utilizing a co-processed superdisintegrant composed of Isabgol mucilage and Crospovidone to facilitate swift tablet disintegration and drug dissolution. Isabgol mucilage was isolated from Isabgol husk and analyzed for its physicochemical properties. The isolated mucilage was co-processed with Crospovidone and evaluated for micrometric characteristics. Five distinct Citicoline ODT formulations (designated F1 through F5) were manufactured via direct compression using varying proportions of the co-processed superdisintegrant. These formulations underwent comprehensive evaluation, including pre-compression and post compression assessments, FTIR analysis for drug-excipient compatibility, wetting and disintegration time measurements, drug content determination, content uniformity testing, and in vitro dissolution profiles The isolated Isabgol mucilage yielded a recovery rate of 33% and demonstrated a swelling index of 310%. The micrometric evaluation of the co-processed superdisintegrant revealed an angle of repose of 26.42°, a Cam's Index of 14.28%, and a Hausner ratio of 1.16. Among the tested formulations, F5 displayed superior overall characteristics, featuring a mean weight of 399 mg, a hardness of 4 kg/cm’, friability of 0.12%, a wetting time of 16 seconds, a disintegration time of 17 seconds, and a drug content of 99.8%. Furthermore, formulation F5 achieved complete (100%) drug release within 30 minutes, with content uniformity maintained between 98.98% and 100.17%. This investigation confirms that the co-processed Isabgol mucilage—Crospovidone system serves as an efficient superdisintegrant for Citicoline ODTs. The optimized F5 formulation demonstrated rapid wetting and disintegration, adequate mechanical integrity, consistent drug distribution, and full drug release, highlighting its viability for the production of Citicoline orally disintegrating tablets.

By Krupaben Jagdishbhai Upadhyay

Hair is the fundamental element of human beauty. Herbs have been used for hair management, cleaning, and decoration since ancient times. Although the use of synthetic materials has grown over time, people are now more aware of the harm they may do to their skin, eyes, and hair. Shampoos and cleansers not only clean hair, but also provide a glossy finish and keep it manageable and oily. Shampoos come in several forms, such as lotion, liquid, powder, gel, and medicinal. caters to specific demands, whether hydrating, volumizing, or treating scalp issues. The market for natural and organic hair care products is expanding due to increased customer awareness of ingredients.